High Air Pollution Days Can Increase the Risk of Asthma-related Hospitalization

In a recent study published in the Journal of Allergy and Clinical Immunology, researchers in Canada studied the effect on aeroallergens and the likelihood of hospitalization due to asthma.  As expected, aeroallergen exposure increased the risk of hospitalization.  However, that risk was amplified significantly on high air pollution days.

Does air pollution increase the effect of aeroallergens on hospitalization for asthma?

Background

Clinical experiments demonstrate that the asthmatic response to an aeroallergen can be enhanced by prior exposure to an air pollutant.

Objective

We sought to compare the effects of ambient aeroallergens on hospitalization for asthma between high and low air pollution days in 11 large Canadian cities.

Methods

Daily time-series analysis was used, and results were adjusted for day of the week, temperature, barometric pressure, and relative humidity.

Results

The relative risk of admission for an interquartile increase in tree pollen levels was 1.124 (95% CI, 1.101-1.147) on days of lower values of fine particulate matter with a median aerodynamic diameter less than or equal to 2.5 μm (PM_2.5) compared with 1.179 (95% CI, 1.149-1.21) on days of higher PM_2.5 values. Significant (P ≤ .05) differences in the relative risks of admission between lower versus higher values of particulate matter with a median aerodynamic diameter less than or equal to 10 μm in diameter were 1.149 (95% CI, 1.118-1.181) versus 1.210 (95% CI, 1.161-1.261) for ascomycetes, 1.112 (95% CI, 1.085-1.14) versus 1.302 (95% CI, 1.242-1.364) for basidiomycetes, 1.159 (95% CI, 1.125-1.195) versus 1.149 (95% CI, 1.129-1.169) for deuteromycetes, and 1.061 (95% CI, 1.016-1.107) versus 1.117 (95% CI, 1.092-1.143) for weeds.

Conclusion

We identified an association between aeroallergens and hospitalizations for asthma, which was enhanced on days of higher air pollution. Minimizing exposure to air pollution might reduce allergic exacerbations of asthma.

• http://dx.doi.org.ezproxyhost.library.tmc.edu/10.1016/j.jaci.2011.09.025, How to Cite or Link Using DOI